Abstract: Current treatments for corneal neovascularization, including topical steroids, nonsteroidal inflammatory agents, fine needle diathermy, argon laser photocoagulation, and photodynamic therapy have limited clinical efficacy. Vascular endothelial growth factor (VEGF) is one of the most important mediators of angiogenesis, and anti-VEGF agents, including avastin, lucentis, VEGF trap and siRNA have excellent efficacy for the treatment of corneal neovascularization. Doxycycline, minocycline and other antibiotics are also confirmed to have inhibitory effect on corneal neovascularization. Immunosuppressive drugs, such as cyclosporine and rapamycin have also been used in the treatment of corneal neovascularization. This paper reviewed the current situation and prospect of medical treatment on corneal neovascularization.  (Int Rev Ophthalmol, 2014, 38: 108-113)